金沙js9线路中心(中国)有限公司

丁辰

发布者:姜楠发布时间:2020-04-15浏览次数:12499


丁辰

博士,教授,博士生导师

青年特聘教授


教育经历和工作经历:

2001-2005年  生物化学与遗传学联合学士学位,爱尔兰都柏林大学(University College Dublin)

2005-2009年 理学博士学位,爱尔兰都柏林大学(University College Dublin)

2009-2013年 博士后研究员,Prof. Dennis Thiele研究组,美国杜克大学(Duke University)

2013年至今 东北大学金沙js9线路中心,教授


简介:

课题组主要从事人类病原酵母菌感染的研究。应用引起肺炎和脑膜炎酵母菌“隐球菌”与小鼠感染模型,探讨真菌金属铜离子,蛋白修饰,蛋白折叠等生物学过程参与真菌致病机制,为抗真菌感染药物的研发提供新思路。国家青年特聘教授,入选沈阳市高层次引进人才“领军人才”,入选辽宁省“兴辽计划青年拔尖人才”,入选“辽宁省百千万人才工程”。其中在《Cell Host & Microbe》、《Nature Chemical Biology》、《Nature Communications》等高水平期刊发表论文。国际遗传学机器大赛(iGEM)指导教师,曾获三金一银。获得中国国家留学基金管理委员会“国家优秀自费留学生奖学金”。入选美国杜克大学“感染学学者”称号。


曾发表论文

(1)Ding C, Butler G, Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formation. Eukaryot Cell, 6, 1310-1319, 2007.

(2)Rossignol T*, Ding C*, Guida A, d’Enfert C, Higgins DG, Butler G*, Correlation between biofilm formation and hypoxic response in Candida parapsilosis. Eukaryot Cell, 4, 550-559, 2009. (co-first)

(3)Holcombe LJ, McAlester G, Munro CA, Enjalbert B, Brown AJP, Gow NA, Ding C, Butler G, Gara F, Morrissey JP, Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans. Microbiology, 156(5), 1476-1486, 2010.

(4)Guida A, Lindstadt C, Maguire SL, Ding C, Higgins DG, Corton NJ, Berriman M, Butler G, Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis. BMC Genomic, 12, 628, 2011.

(5)Samanovic MI*, Ding C*, Thiele DJ, Darwin H, Copper in microbial pathogenesis: Meddling with the metal. Cell Host & Microbe, 11(2), 106-115, 2011. (co-first)

(6)Ding C, Yin J, Tovar E, Fitzpatrick DA, Higgins DG, Thiele DJ, The copper regulon of the human fungal pathogen Cryptococcus neoformans H99. Molecular Microbiology, 81(6), 1560-1576, 2011.

(7)Ding C,Vidanes GM, Maguire SJ, Guida A, Synnott JM, Andes DR, Butler G, Dissection of the role Bcr1 in C. albicans and C. parapsilosis. PLoS One, 6(12), e28151, 2011.

(8)Ding C, Festa R, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ, Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host & Microbe, 13(3), 265-276, 2013. (Recommended by Faculty of 1000 and Nature Reviews Microbiology)

(9)Palacios O, Espart A, Espín J,Ding C,Thiele DJ, Atrian S, Capdevila M, Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors. Metallomics. 2013 Dec 6

(10)Ding C, Festa R, Sun T-S, Wang Z-Y, Iron and copper as virulence modulators in human fungal pathogens. Molecular Microbiology, doi:10.1111/mmi.12653,2014

(11)Ding C, Hu G, Jung WH, Kronstad JW, Essential metals in Cryptococcus neoformans: Acquisition and Regulation. Curr Fungal Infect Rep. 2014 (8):153-162

(12)Sun T-S, Ju X, Gao HL, Wang T, Thiele DJ, Li J-Y, Wang Z-Y, Ding C. Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. Nature Communications, 5:5550, 2014 (Recommended by Nature Reviews Microbiology)

(13)Guo C, Zhang S, Li JY, Ding C, Yang ZH, Chai R, Wang X, Wang ZY. Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model. Scientific Reports. 2016 Jul 12;6:29396. doi: 10.1038/srep29396

(14)Tian B, Yan Q, Wang J, Ding C, Sai S. Enhanced antifungal activity of voriconazole-loaded nanostructured lipid carriers against Candida albicans with a dimorphic switching model. Int J Nanomedicine. 2017 Sep 26;12:7131-7141. Doi:10.2147/IJN.S145695

(15)Do E, Park S, Li M-H, Wang J-M, Ding C,Kronstad, JW, Jung, WH. The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans. Medical Mycology. 2017. Myx073.

(16)Suo C-H, Ma L-J, Li H-L, Sun J-F, Li C, Lin M-H, Sun T-S, Du W, Li Y-J, Gao X-D, Meng Y, Sai S-S, Ding C. Investigation of Cryptococcus neoformans magnesium transporters reveals important role of vacuolar magnesium transporter in regulating fungal virulence factors. MicrobiologyOpen. 2017. DOI:10.1002/mbo3.564.

(17)Garcia-Santamarina SFesta RASmith ADYu CHProbst CDing C,Homer CMYin JNoonan JPMadhani HPerfect JRThiele DJ. Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. Molecular Microbiology. 2018. Apr 2. doi: 10.1111/mmi.13960.

(18)李焱剑,高鑫迪,孟阳,丁辰.铜、铁离子代谢调节隐球菌致病力及宿主免疫的研究进展。Mycosystema(菌物学报). 2018 Oct 22, 37(10):1337-1348. (Invited review)

(19)Zhu Q, Xiahou J, Guo Y, Li H, Ding C, Wang J, Li X, Sun X, Li JG. Zn3Ga2Ge2O10: Cr3+ Uniform Microspheres: Template-Free Synthesis, Tunable Bandgap/Trap Depth, and In Vivo Rechargeable Near-Infrared-Persistent Luminescence. ACS Applied Bio Materials. 2018 Dec 28; 2(1): 577-87.

(20)Cao M, Li D, Lin Z, Niu C, Ding C. MiRNN: An Improved Prediction Model of MicroRNA Precursors Using Gated Recurrent Units. International Conference on Intelligent Computing 2018 Aug 15 (pp. 217-222). Springer, Cham.

(21)Li C, Li Y, Ding C. The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi. International Journal of Molecular Science. 2019 Jan 5;20(1). Pii: E175. Doi:10.3390/ijms20010175. (Invited review)

(22)Li Y, Li H, Sui, M, Li M, Wang J, Meng Y, Sun T, Liang Q, Suo C, Gao X, Li C, Li Z, Du W, Zhang B, Sai S, Zhang Z, Ye J, Wang H, Yue S, Li J, Zhong M, Chen C, Qi S, Lu L, Li D, Ding C*. Fungal acetylome comparative analysis identifies an essential role of acetylation in human fungal pathogen virulence. Communications Biology. 2019, 2, 154.

(23)Hailong Li, Yanjian Li, Tianshu Sun, Wei Du, Chao Li, Chenhao Suo, Yang Meng, Qiaojing Liang, Tian Lan, Manli Zhong, Sheng Yang, Cheng Niu, Dancheng Li, Chen Ding. Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primates. PLoS Neglected Tropical Diseases, 2019, 13(7): e0007566.

(24)Du, W., Li, H., Tian, B., Sai, S., Gao, Y., Lan, T., ... &Ding, C. (2019). Development of nose-to-brain delivery of ketoconazole by nanostructured lipid carriers against cryptococcal meningoencephalitis in mice. Colloids and Surfaces B: Biointerfaces, 183, 110446.

(25)XiuQingxiao, Li Dancheng, Li Hailong, Wang Ning, Ding Chen. Prediction Method for Lysine Acetylation Sites Based on LSTM Network2019 IEEE 7th International Conference on Computer Science and Network Technology (ICCSNT), accept.

(26)Mao Lin, Zhenlei Liu, Gang Liu, Sen Zhao, Chao Li, Weisheng Chen, Zeynep Coban Akdemir, Jiachen Lin, Xiaofei Song, Shengru Wang, Qiming Xu, Yanxue Zhao, Lianlei Wang, Yuanqiang Zhang, Zihui Yan, Sen Liu, Jiaqi Liu, Yixin Chen, Xu Yang, Tianshu Sun, Xin-Zhuang Yang, Yuchen Niu, Xiaoxin Li, Wesley You, BintaoQiu, Chen Ding, Pengfei Liu, Shuyang Zhang, Claudia M. B. Carvalho, Jennifer E. Posey, GuixingQiu, JamesR. Lupski, Zhihong Wu, Jianguo Zhang, Nan Wu. (2019) Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1. Molecular Genetics & Genomic Medicine, DOI:10.1002/mgg3.1023.

(27)Sarela Garcia-Santamarina, Corinna Probst, Chen Ding, Pamela Riggs-Gelasco, Steven Conklin, Katherine J. Franz, Lisa Kinch, Nick Grishin, Leila Lo Leggio, Katja Salomon Johansen and Dennis J. Thiele (2019). A Lytic Polysaccharide Monooxygenase family member functions in Cu+ import and fungal meningitis. Nature Chemical Biology, 16, 345-350, 2020

(28)Hailong Li, Yanjian Li, Tiabshu Sun, Wei Du, Zhijie Zhang, Dancheng Li and Chen Ding(2020). Integrative Proteome and Acetylome Analyses of Murine Responses to Cryptococcus neoformans Infection. Frontiers in Microbiology, 11:575. Doi 10.3389/fmicb.2020.00575, 2020 (In press)