金沙js9线路中心(中国)有限公司

王天怡

发布者:姜楠发布时间:2022-07-07浏览次数:1204

王天怡博士,副教授,硕士生导师,国家自然科学基金审评专家。2013年毕业于沈阳药科大学临床药学专业,获得博士学位,同年进入东北大学工作。作为负责人主持国家自然科学基金面上项目,国家自然科学基金青年项目,辽宁省自然科学基金项目,教育部及中央高校等多项课题。在国际学术期刊发表SCI论文10余篇。参编教材《生物化学》。

研究方向:1外泌体在肿瘤发生过程中对肿瘤微环境的影响。2药物的靶向递送;3癌症、阿尔兹海默病等疾病发生的分子机制,探索新的治疗靶点,针对新靶点的抗体筛选和抗体基因胞内递送表达

主持基金项目

1. 国家自然科学基金青年项目:BAP31胞内抗体的构建及其影响肿瘤干细胞增殖与分化的机制研究。No31500754

2. 国家自然科学基金面上项目:BAP31胞内抗体经外泌体microRNA抑制胃癌转移的作用及机制研究。No31972898。  

3. 辽宁省自然科学基金项目:癌细胞良性分化靶点及其胞内抗体新药筛选与机制研究

4. 国家教育部项目:基于大数据智能分析的精准肿瘤诊疗模式探索

5.中央高校基本科研业务费项目:细胞内抗体定向封闭膀胱癌干细胞致癌通路研究

6. 中央高校基本科研业务费项目:BAP31对阿尔兹海默病淀粉样蛋白产生的影响及机制研究

发表论文10余篇

1. Tianyi Wang, Jing Chen,Yue Hou,Yang Yu, Bing Wang*. BAP31 deficiency contributes to the formation of amyloid-β plaques in Alzheimer’s diseaseby reducing the stability of RTN3.33:4936-4946, 2019. IF:5.4.

2. Jing Chen1, Haotian Guo1,Tianyi Wang*, Bing Wang*. A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation. 144: 2051-2062, 2019.IF:5.0.

3.Tianyi Wang, Peng Zhao Siling Wang et al. The mechanism for increasing the oral ioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier. 23:420-428, 2016. IF:6.6

4.Tianyi WangHaitao JiangLongWan, et al. Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery. 13:354–363. 2015. IF:6.0

5. Tianyi Wang, Haitao Jiang, Meijuan Zou*Gangcheng* , et al. Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: Effect of silica architecture on immunological properties.International Journal of Pharmaceutics. 436:351-358, 2012. IF:3.6

6.Tianyi Wang, Meijuan Zou, Gangcheng*, et al.Synthesis of a novel kind of carbon nanoparticle with large mesopores and macropores and its application as an oral vaccine adjuvant.European Journal of Pharmaceutical Sciences. 44:653-659. 2011. IF:3.5

7. Haitao Jiang, Tianyi Wang, Siling Wanget al. Dvelopment of an amorphous mesoporous TiO2 nanosphere as a novel carrier for poorly water-soluble drugs: Effect of different crystal forms of TiO2 carriers on drug loading and release behaviors. Microporous and Mesoporous Materials. 153:124–130, 2012. IF:3.6

8. Qinfu Zhao, Tianyi Wang, Siling Wanget al. Fabrication of mesoporous hydroxycarbonate apatite for oral delivery of poorly water-soluble drug carvedilol. Journal of Non-Crystalline Solids. 358: 229–235, 2012, IF:2.5

9. Yuting Li, Tianyi Wang, Siling Wanget al. Functional and unmodified MWNTs for delivery of the water-insoluble drug Carvedilol–A drug-loading mechanism. Applied Surface Science.  257:5663–5670, 2011. IF:4.4

10. Qinfu Zhao, Tianyi Wang, Siling Wanget al. Template-directed hydrothermal synthesis of hydroxyapatite as a drug delivery system for the poorly water-soluble drug carvedilol. Applied SurfaceScience. 257:10126-10133, 2011. IF:4.4